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When this issue occurs during installation, an UnauthorizedAccessException at Microsoft.SharePoint.SPFeature.Activate() is logged to the SharePoint trace log. When deactivation fails as a part of un-installation, an UnauthorizedAccessException is displayed on the last setup screen for the failed deactivation(s).
To prevent this issue, grant portal administrators the permission to manage MySite Web application:
Go to SharePoint Central Administration and select the Application Management tab.
Choose Policy for Web Application under the Application Security group.
Make sure you select the correct Web Application for your “My Site” in the Web Application list on the right.
Select Add Users on the upper left.
Choose All Zones by default on the Add Users screen and click Next.
Add the appropriate user(s) or active directory group that you want to have control over your “My Site” Web Application.
Select the level of control.
Adding users and setting the control level

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