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Add Protection in Worksheet
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Aspose.Cells for GridDesktop allows you to protect cells in a worksheet. First you need to protect your worksheet, then you can protect your desired cells in the worksheet. In order to protect the worksheet, please set Worksheet.Protected property to true, then use Worksheet.SetProtected() method to protect the range of cells.
Protect Cells using Aspose.Cells.GridDesktop
The following sample code protects all the cells in range A1:B1 of the active worksheet of GridDesktop. When you double‑click any cell in this range, you will not be able to edit it. It will make these cells read‑only.