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Delete Worksheets from Workbooks
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You can delete any worksheet in a workbook. To delete a worksheet, use the worksheet host item or access the worksheet by using the sheets collection of the workbook.
VSTO
Excel.Workbook myWorkbook= this.Application.Workbooks.Open(fileName);
myWorkbook.Sheets[2].Delete();
Aspose.Cells
Workbook myWorkbook = new Workbook(fileName);
myWorkbook.Worksheets.RemoveAt(1);
myWorkbook.Save(fileName);