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Aspose.Cells allows you to filter or remove defined names present inside the workbook. Please use LoadDataFilterOptions.DefinedNames to load defined names and use ~LoadDataFilterOptions.DefinedNames~ to remove them while loading the workbook. Please note that if you remove defined names, formulas inside the workbook may break.
The following sample code loads the sample Excel file which has a formula in cell C1 containing the defined names, i.e., =SUM(MyName1, MyName2). Since we are using ~LoadDataFilterOptions.DefinedNames~ to remove the defined names while loading the workbook, the formula in cell C1 of the output Excel file breaks, and you see #NAME? instead. Please see the following screenshot that shows the effect of the code on the sample Excel file.

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